Simone is a researcher at the School of Architecture, Planning and Landscape, Newcastle University, where he works on the design of Living Architecture, an EU-funded project that operates at the intersection of architecture, building construction, bio-energy and synthetic biology.

He is a member, with Rachel Armstrong and Rolf Hughes, of the Experimental Architecture Group (EAG), a collective whose work has been exhibited and performed at the Venice Art Biennale, Trondheim Biennale, Allenheads Contemporary Arts, Culture Lab, and the Tallinn Architecture Biennale.

Simone is the founder and editor of the online journal Organs Everywhere (Œ), and the Director of the Œ Case Files, imprint in collaboration with Punctum Books— a platform for profanatory and experimental practices that fundamentally question architecture’s boundaries, technologies, methods and evaluation systems. Other notable publications include articles in 306090, Thresholds, Architecture Design Research (Ardeth), Volume, Kerb, ARCH:RESEARCH Journal; the co-edited volume Unconventional Computing: Design Methods for Adaptive Architecture (ACADIA 2013) and chapters in several forthcoming books about experimental modes of architectural research and construction.